Evoluci車n temporal de las plaquetas y los anticuerpos antiplaquetarios en pacientes de 芍rea end谷mica con malaria no complicada

作者：Rios Orrego; A; alvarez Castillo; T; Carmona Fonseca; J; Blair Trujillo; S

来源：Anales de Medicina Interna, 2005.

DOI：10.4321/S0212-71992005001200002

• thrombocytopenia
• anti-platelets antibodies
• malaria
• flow cytometry.

aim: to evaluate the number of platelets and the title of anti-platelet antibodies igg ac-pi (by flow cytometry) in patients with non-complicated malaria. methods: descriptive, prospective and longitudinal study from 45 patients (aged among 14-67). thirty patients were followed during 7 days. results: a) pretreatment: it was found malarial thrombocytopenia (mt) in 71 % and significant association between mt and ac-pi in 33 %. mt was not associated to residence zone, to have had malaria in the last year and plasmodium species but sex associated (males, p= 0,02078195), although, the ac-pi titers of male and female was similar. correspondingly, the number of platelets was statistically similar to the values of above variables. there was a low and an inverse lineal correlation between platelets and titres of ac-p1 (r= -0,342 (p= 0,02310)). b) during the following, multiple linear regression among platelets, age, years of residence in the zone, number of malaria episodes in the last year, parasitaemia (logarithmically expressed) and ac-p1 titers showed no significant coefficient and the maximum explanation achieved (17%) was parasitaemia and ac-p1 titers. similar analysis among ac-p1 and age, years of residence in the zone number of malaria episodes in the last year, parasitaemia (logarithmically expressed) showed that the first three explain 38 % of the changes in ac-p1, whereas malaria episodes and years of residence in the zone explain 28%.

• 出版日期2005