Abortive keratoacanthoma: a hitherto unrecognised variant

作者：Weedon David^*; Brooks David; Malo Jonathan; Williamson Richard

来源：Pathology, 2010, 42(7): 661-663.

DOI：10.3109/00313025.2010.522176

• Keratoacanthoma
• regression
• lichenoid change

Aims: To study the histological features of abortive keratoa-canthoma, a variant that has only recently been recognised.
Methods: A key word search of the database of our pathology practice was carried out for all keratoacanthomas (KAs) reported by one author (DW) over a 14-month period. These cases were then sorted into histological subtypes by age in decades.
Results: A total of 3465 cases of KA were reported over this period, of which 582 (16.8%) were of the so-called abortive type. Abortive KAs are characterised by rapid growth and subsequent lichenoid regression at an early stage in their evolution. Lichenoid changes extend for a variable distance beyond the lesion.
Conclusions: Abortive KA is a hitherto unrecognised variant of KA which may be misdiagnosed as squamous cell carcinoma despite its distinctive features. Lichenoid regression, rather than terminal differentiation, is the main mechanism of its involution.

• 出版日期2010-12