MAPPING HOMEOSTATIC SYNAPTIC PLASTICITY USING CABLE PROPERTIES OF DENDRITES

作者：Queenan B N; Lee K J; Tan H; Huganir R L; Vicini S; Pak D T S^*

来源：Neuroscience, 2016, 315: 206-216.

DOI：10.1016/j.neuroscience.2015.12.017

• homeostatic synaptic plasticity
• AMPA receptors
• dendritic origin
• current shape
• dendritic filtering index
• mEPSC slope

When chronically silenced, cortical and hippocampal neurons homeostatically upregulate excitatory synaptic function. However, the subcellular position of such changes on the dendritic tree is not clear. We exploited the cable-filtering properties of dendrites to derive a parameter, the dendritic filtering index (DFI), to map the spatial distribution of synaptic currents. Our analysis indicates that young rat cortical neurons globally scale AMPA receptor-mediated currents, while mature hippocampal neurons do not, revealing distinct homeostatic strategies between brain regions and developmental stages. The DFI presents a useful tool for mapping the dendritic origin of synaptic currents and the location of synaptic plasticity changes.

• 出版日期2016-2-19