Binding Bacteria to Highly Branched Poly(N-isopropyl acrylamide) Modified with Vancomycin Induces the Coil-to-Globule Transition

作者：Shepherd Joanna; Sarker Prodip; Swindells Kathryn; Douglas Ian; MacNeil Sheila; Swanson Linda; Rimmer Stephen^*

来源：Journal of the American Chemical Society, 2010, 132(6): 1736-+.

DOI：10.1021/ja907466y

Binding of highly branched poly(N-isopropylacrylamide) with vancomycin end groups to Staphylococcus aureus induced a coil-to-globule phase transition. The polymers aggregated this Gram-positive bacteria (but not Gram-negative bacteria) over a wide range of temperatures, but cooling to 24-26 degrees C progressed the polymer-bound bacteria through a globule-to-coil phase transition, after which the bacteria were released.

• 出版日期2010-2-17