A Three-Dimensional Quantitative Method to Measure Meniscus Shape, Position, and Signal Intensity Using MR Images: A Pilot Study and Preliminary Results in Knee Osteoarthritis

作者：Wirth Wolfgang^*; Frobell Richard B; Souza Richard B; Li Xiaojuan; Wyman Bradley T; Le Grayerand Marie Pierre Hellio; Link Thomas M; Majumdar Sharmila; Eckstein Felix

来源：Magnetic Resonance in Medicine, 2010, 63(5): 1162-1171.

DOI：10.1002/mrm.22380

• meniscus
• osteoarthritis
• extrusion
• coverage

This pilot study presents a technique for three-dimensional and quantitative analysis of meniscus shape, position, and signal intensity and compares results in knees with (n = 20) and without (n = 11) radiographic osteoarthritis. 3-T MR images with 2mm section thickness were acquired using a proton density weighted, fat-suppressed, coronal, fast spin-echo sequence. Segmentation of the tibial, femoral, and external surface of the medial meniscus and the tibial joint surface was performed. Three-dimensional parameters were computed to describe the shape, position, and signal intensity of the entire meniscus and three subregions (body, anterior, and posterior horn). Key results included a greater size (i.e., volume, surface areas, and thickness), increased medial extrusion (i.e., greater extrusion distance, greater meniscal area uncovered by tibial surface), and elevated signal intensity of the medial meniscus in osteoarthritis than in nonosteoarthritis knees, particularly in the meniscus body. These results need to be confirmed in larger cohorts, preferably under weight-bearing conditions. Magn Reson Med 63:1162-1171, 2010.

• 出版日期2010-5