Antimalarial beta-Carboline and Indolactam Alkaloids from Marinactinospora thermotolerans, a Deep Sea Isolate

作者：Huang, Hongbo; Yao, Yueliang; He, Zhengxiang; Yang, Tingting; Ma, Junying; Tian, Xinpeng; Li, Yayong; Huang, Caiguo; Chen, Xiaoping; Li, Wenjun; Zhang, Si; Zhang, Changsheng; Ju, Jianhua^*

来源：Journal of Natural Products, 2011, 74(10): 2122-2127.

DOI：10.1021/np200399t

• SOUTH CHINA SEA
• MARINE VERRUCOSISPORA STRAIN
• SP NOV.
• LYNGBYATOXIN-A
• GEN. NOV.
• ACTINOMYCETE
• TELEOCIDIN
• BIOSYNTHESIS
• NOCARDIOPSIS
• METABOLITES

Four new beta-carboline alkaloids, designated marinacarbolines A D (1-4), two new indolactam alkaloids, 13-N-demethyl-methylpendolmycin (5) and methylpendolmy-cin-14-O-alpha-glucoside (6), and the three known compounds 1-acetyl-beta-carboline (7), methylpendolmycin (8), and pendolmycin (9) were obtained from the fermentation broth of Marinactinospora thermotolerans SCSIO 00652, a new actinomycete belonging to the family Nocardiopsaceae. Their structures were elucidated by extensive MS and ID and 2D NMR spectroscopic data analyses. The structure of compound I was further confirmed by single-crystal X-ray crystallography. The new compounds 1-6 were inactive against a panel of eight tumor cell lines (IC50 > 50 mu M) but exhibited antiplasmodial activities against Plasmodium falciparum lines 3D7 and Dd2, with IC50 values ranging from 1.92 to 36.03 mu M.

• 出版日期2011-10
• 单位中国科学院广州生物医药与健康研究院; 云南大学; 呼吸疾病国家重点实验室; 中国人民解放军第二军医大学