HLA-DRB1 and HLA-DQB1 alleles in Chinese Han patients with Juvenile-Onset recurrent respiratory papillomatosis

作者：Zhao, Jing; Wang, Guoliang; Wang, Guixiang; Wang, Hua; Wang, Shengcai; Tai, Jun; Tang, Lixing; Gui, Jingang; Zhang, Jie^*; Ni, Xin^*

来源：International Journal of Pediatric Otorhinolaryngology, 2017, 102: 119-122.

DOI：10.1016/j.ijporl.2017.04.017

• Aggressive
• Chinese Han population
• HLA
• Human papilloma virus (HPV)
• Juvenile-Onset recurrent respiratory Papillomatosis (JORRP)

Juvenile-Onset recurrent respiratory papillomatosis (JORRP) is a rare benign neoplasm of the respiratory mucosa caused by human papilloma virus. Previous studies on the possible associations between HLA alleles and JORRP have shown various results in different ethnic groups. The present study aims to investigate the association between JORRP and HLA class II DRBland DQB1 alleles in Chinese Han children. We found that the frequencies of HLA-DRB1*03:01 (p(c) = 0.0378, OR = 4.8) and HLA-DQB1 *02:01 (p(c) = 0.021, OR = 4.8) alleles were significantly higher in patients with JORRP than in controls. In addition, HLA-DRB1*03:01 allele significantly correlated with aggressive JORRP (r = 0.467, p = 0.009). This was the first study on the HLA alleles in Chinese Han patients with JORRP. Future studies are required to further elucidate the correlation of HLA class II alleles and susceptibility to JORRP.

• 出版日期2017-11
• 单位首都医科大学