Antibody response in MOG(35-55) induced EAE

作者：Lalive Patrice H; Molnarfi Nicolas; Benkhoucha Mandia; Weber Martin S; Santiago Raber Marie Laure^*

来源：Journal of Neuroimmunology, 2011, 240: 28-33.

DOI：10.1016/j.jneuroim.2011.09.005

• Experiemntal Autoimmune Encephalomyelitis
• Multiple Sclerosis
• B cell response
• Anti-DNA
• Anti-RNA
• Anti-MOG

Neurological deficit in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis is widely considered to be a consequence of synergistic T and B cell responses to central nervous system (CNS) antigens. We show that mice immunized with encephalitogenic myelin oligodendrocyte glycoprotein (MOG(35-55)) peptide develop significant serum levels of anti-MOG antibodies in parallel with disease progression. Furthermore, EAE mice developed antibodies against DNA and RNA, a serological hallmark observed in autoimmune diseases such as systemic lupus erythematosus. The presence of anti-nucleic responsive B cells and antibodies during EAE may highlight a previously unappreciated mechanism in the pathogenesis of CNS autoimmunity.

• 出版日期2011-12-15