Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats

作者：Gao Wei; Li Hai Ying; Wang Li Xin; Hao Li Jun; Gao Jian Li; Zheng Rong Juan; Cai Chun Jiang; Si Yan Ling^*

来源：Asian Pacific Journal of Tropical Medicine, 2014, 7(5): 402-406.

DOI：10.1016/S1995-7645(14)60065-1

• Omeprazole
• Cirrhotic portal hypertension
• Gastric mucosal injury
• Prostaglandins
• Tumor necrosis factor-alpha

Objective: To observe the protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats. Methods: All rats were randomly divided into normal control group, cirrhosis and treatment group. Thioacetamide was used to establish rat model of cirrhotic portal hypertension. The necrotic tissue of gastric mucosa ulcer focus, degree of neutrophils infiltration at the ulcer margin, portal pressure, portal venous flow, abdominal aortic pressure, abdominal aortic blood flow at front end, gastric mucosal blood flow (GMBF), glycoprotein (GP) of gastric mucosa,basal acid secretion, H+ back diffusion, gastric mucosal damage index, NO, prostaglandin E-2 (PGE(2)) and tumor necrosis factor-alpha (TNF-alpha) were determined respectively, and the pathological changes of gastric mucosa were also observed by microscope. Results: Compared with cirrhosis group and the control group, the ulcer bottom necrotic material, gastric neutrophil infiltration and UI of the treatment group were all decreased significantly (P<0.01), GMBF value, GP values, serum NO, PGE(2), TNF-alpha were all significantly increased. Conclusions: Omeprazole has an important protective effect on gastric mucosal and it can increase gastric mucosal blood flow and related to many factors.

• 出版日期2014-5