Distinct effects of fixed combinations of valsartan with either amlodipine or hydrochlorothiazide on lipoprotein subfraction profile in patients with hypertension

作者：Christogiannis L G; Kostapanos M S; Tellis C C; Milionis H J; Tselepis A D; Elisaf M S^*

来源：Journal of Human Hypertension, 2013, 27(1): 44-50.

DOI：10.1038/jhh.2011.108

• valsartan
• amlodipine
• hydrochlorothiazide
• lipoprotein subfractions
• low-density-lipoprotein particle size

The effect of antihypertensive drugs on lipoprotein subfraction profile is still under investigation. In this study the effects of fixed combination of valsartan with either amlodipine (V-A) or hydrochlorothiazide (V-H) on low-density-lipoprotein (LDL) and high-density-lipoprotein (HDL) subfraction profile of patients with stage 2 or 3 hypertension were assessed. A total of 60 drug-naive patients were randomized to either V-A (160/5 mg, n = 30) or V-H (160/12.5 mg, n = 30). At baseline as well as 16 weeks post-treatment analysis of the LDL and HDL subfraction profile was conducted by using LDL Lipoprint System. Both V-A and V-H effectively reduced blood pressure (BP) to similar levels. An increase in the cholesterol concentration of small-dense LDL subfractions (by 18.2%, P%26lt;0.05) was observed in the V-H group, whereas this parameter remained unchanged in the V-A group. Therefore, mean LDL particle size was decreased in the V-H group (from 267 +/- 5 to 266 +/- 5 angstrom, P%26lt;0.05). HDL-Cholesterol (HDL-C) levels were reduced by 4.7% (P%26lt;0.05) in the V-H group, mirrored by a reduction in the cholesterol mass of small and intermediate HDL particles. In conclusion, despite similar reductions in BP, V-H combination may adversely affect serum lipids as well as LDL and HDL subfraction profile as compared with V-A. Journal of Human Hypertension (2013) 27, 44-50; doi:10.1038/jhh.2011.108; published online 1 December 2011

• 出版日期2013-1