Drug release patterns of malic acid-butane 1,4-diol-glycerol and phthalic acid-butane 1,4-diol-glycerol co-polyesters

作者：Bakr M A^*; Mahmud A; Hasnat M E

来源：Journal of Polymer Materials, 2008, 25(1): 111-117.

• malic acid-butane 1
• 4-diol-glycerol and phthalic acid-butane 1
• 4-diol-glycerol co-polyesters
• enteric coating material
• diclofenac sodium core tablets
• drug release profile

Malic acid-butane 1, 4-diol-glycerol and phthalic acid-butane 1, 4-diol-glycerol co-polyesters were synthesized and characterized by their IR-spectra, molecular weights, solubility in common organic solvents, equilibrium swelling behavior in water and ethanol, elemental analyses, melting points, hydrolytic and soil degradation tests. By using Dean-Stark apparatus, the synthesis procedure was carried out with xylene as reaction medium and anhydrous FeCl(3) as catalyst. The co-polyesters remained unchanged in simulated gastric fluid (pH 1.2) and gradually degraded in simulated intestinal fluid (pH 7.4). They were later tried as enteric coating materials on diclofenac sodium core tablets and their drug release patterns correspond to BP standard drug release profile of enteric coating material.

• 出版日期2008-3