Association of Myocardial T1-Mapping CMR With Hemodynamics and RV Performance in Pulmonary Hypertension

作者：Garcia Alvarez Ana; Garcia Lunar Ines; Pereda Daniel; Fernandez Jimenez Rodrigo; Sanchez Gonzalez Javier; Mirelis Jesus G; Nuno Ayala Mario; Sanchez Quintana Damian; Fernandez Friera Leticia; Garcia Ruiz Jose M; Pizarro Gonzalo; Agueero Jaume; Campelos Paula; Castella Manuel; Sabate Manel; Fuster Valentin; Sanz Javier; Ibanez Borja^*

来源：JACC: Cardiovascular Imaging , 2015, 8(1): 76-82.

DOI：10.1016/j.jcmg.2014.08.012

• equilibrium contrast
• extracellular volume
• magnetic resonance
• native T1
• pulmonary hypertension
• T1 mapping

Early detection of right ventricular (RV) involvement in chronic pulmonary hypertension (PH) is essential due to prognostic implications. T1 mapping by cardiac magnetic resonance (CMR) has emerged as a noninvasive technique for extracellular volume fraction (ECV) quantification. We assessed the association of myocardial native T1 time and equilibrium contrast ECV (Eq-ECV) at the RV insertion points with pulmonary hemodynamics and RV performance in an experimental model of chronic PH. Right heart catheterization followed by immediate CMR was performed on 38 pigs with chronic PH (generated by surgical pulmonary vein banding) and 6 sham-operated controls. Native T1 and Eq-ECV values at the RV insertion points were both significantly higher in banded animals than in controls and showed significant correlation with pulmonary hemodynamics, RV arterial coupling, and RV performance. Eq-ECV values also increased before overt RV systolic dysfunction, offering potential for the early detection of myocardial involvement in chronic PH.

• 出版日期2015-1