Association of the IL-10 Receptor A536G (S138G) Loss-of-Function Variant with Recurrent Miscarriage

作者：Magdoud Kalthoum; Hellal Radhia; Zemni Ramzi; Touraine Renaud; Mahjoub Touhami; Almawi Wassim Y^*

来源：American Journal of Reproductive Immunology, 2014, 72(1): 1-4.

DOI：10.1111/aji.12227

• IL-10 receptor
• polymorphisms
• pregnancy
• recurrent miscarriage

Problem We investigated the association of interleukin-10 receptor (IL10R1) loss-of-function variant A536G/S138G with recurrent pregnancy loss (RPL). Method of study Study subjects comprised 300 women with 3 miscarriages, and 350 control women. Results Significantly higher 536G-allele frequency was seen in RPL cases, thus assigning pathogenic role for this allele. Significant difference in A536G/S138G genotypes distribution was seen between RPL cases and controls, evidenced by enrichment of 536A/G and 536G/G genotypes in RPL cases. Setting A/A genotype as reference (OR=1.00), increased RPL risk was seen with 536A/G, and more in 536G/G carriers, thereby establishing dose-dependency. Conclusion IL10R1 loss-of-function A536/S138G polymorphism may contribute to RPL pathogenesis.

• 出版日期2014-7