An efficient catalytic method for the Friedlander annulation mediated by peptide coupling agent propylphosphonic anhydride (T3P (R))

作者：Augustine John Kallikat^*; Bombrun Agnes; Venkatachaliah Srinivasa

来源：Tetrahedron Letters, 2011, 52(50): 6814-6818.

DOI：10.1016/j.tetlet.2011.10.048

• Friedlander annulation
• Propylphosphonic anhydride
• Quinolines
• Catalytic
• Microwave irradiation

We have demonstrated the utilization of T3P, a mild and low toxic peptide coupling agent, as a promoter and water scavenger in the Friedlander annulation, and thus introduced a highly efficient catalytic process to access carbocyclic and heterocyclic fused quinolines under microwave irradiation or a conventional heating technique. The reaction conditions are sufficiently mild to tolerate the acid and base sensitive functional groups that can serve as levers for further extension of the quinoline products.

• 出版日期2011-12-14