科研之友
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摘要
Alzheimer's disease (AD) is a progressive neurodegenerative disorder which usually occurs in the elderly. The accumulation of beta-amyloid and the formation of neurofibrillary tangles are considered as the main pathogenies of AD. Research suggests that beta-secretase 1 (BACE1) plays an important role in the formation of beta-amyloid. Discovery of new BACE1 inhibitors has become a significant method to slow down the progression of AD or even cure this kind of disease. This review summarizes the different types and the structural modification of these new BACE1 inhibitors.
- 出版日期2017-1
- 单位南京中医药大学
