A New Injectable Thermogelling Material: Methoxy Poly(ethylene glycol)-Poly(sebacic acid-D,L-lactic acid)-Methoxy Poly(ethylene glycol) Triblock Co-polymer

作者：Zhai, Yinglei; Deng, Liandong; Xing, Jinfeng; Liu, Yu; Zhang, Qiang; Dong, Anjie^*

来源：Journal of Biomaterials Science, Polymer Edition, 2009, 20(7-8): 923-934.

DOI：10.1163/156856209X444349

• Poly(ester-anhydride)
• thermogelling
• sol-gel transition
• biodegradable
• drug delivery

A novel injectable thermogelling poly(ester-anhydride) co-polymer, methoxy poly(ethylene glycol) poly(sebacic acid-D,L-lactic acid)-methoxy poly(ethylene glycol) (mPEG-poly(SA-LA)-mPEG) triblock co-polymer, was prepared by melt-condensation polymerization. The synthesized triblock co-polymer was characterized by FT-IR and H-1-NMR. The aqueous solutions of mPEG-poly(SA-LA)-mPEG underwent sol-gel precipitation transition when the temperature was increased from 20 to 70 degrees C, depending on the concentration of the polymer. 5-FU, as the model drug, was mixed into the gel in a low-viscous sol state at room temperature. About 63 wt% of the loaded 5-FU could be released in vitro from the gel over 72 h at 37 degrees C. Subcutaneous injection of 25 wt% mPEG-poly(SA-LA)-mPEG aqueous solution resulted in the formation of a in situ gel depot in a rat model, which sustained for longer time than that of Pluronic F-127 aqueous solution. The biodegradable thermogelling mPEG-poly(SA-LA)-mPEG triblock co-polymer is believed to be a promising candidate for drug-delivery applications.

• 出版日期2009
• 单位北京大学; 天津大学