Determination of CEM-101 Activity Tested against Clinical Isolates of Neisseria meningitidis from a Worldwide Collection

作者：Biedenbach Douglas J; Castanheira Mariana; Jones Ronald N^*

来源：Antimicrobial Agents and Chemotherapy, 2010, 54(9): 4009-4011.

DOI：10.1128/AAC.01812-09

The activity of CEM-101, a fluoroketolide, was compared to those of 11 other antimicrobial agents using the reference broth microdilution method tested against 103 Neisseria meningitidis strains, including ciprofloxacin-nonsusceptible isolates with confirmed gyrA (T91I) mutations. Among the tested isolates, 79.6% were serogroup B or C and all isolates were susceptible to ceftriaxone, azithromycin, minocycline, and rifampin. However, penicillin-nonsusceptible strains were observed (15.5%) and susceptibility to trimethoprim-sulfamethoxazole was only 50.5%. CEM-101 was the most active macrolide-like compound (MIC(90), <= 0.015 mu g/ml) compared with MIC(90)s of telithromycin (MIC(90), 0.03 mu g/ml), azithromycin and clarithromycin (MIC90, 0.12 mu g/ml), and erythromycin (MIC(90), 0.25 mu g/ml). CEM-101 could provide a potent alternative for the prophylaxis of meningococcal disease.

• 出版日期2010-9