A. cantoniensis Inhibits the Proliferation of Murine Leukemia WEHI-3 Cells In Vivo and Promotes Immunoresponses In Vivo

作者：Tan Tzu Wei; Lin Yuh Tzy; Yang Jai Sing; Lu Chi Cheng; Chiang Jo Hua; Wu Chang Lin; Lin Jing Pin; Tang Nou Ying; Yeh Chin Chung; Fan Ming Jen; Chung Jing Gung^*

来源：In Vivo, 2009, 23(4): 561-566.

• A. cantoniensis (AC)
• WEHI-3 leukemia cells
• BALB/c mice
• immune response
• NK cells

Ampelopsis cantoniensis (AC) has been used as a folk medicine for reducing pain in the Taiwanese population. Our previous studies have shown that the crude extract of AC induced apoptosis in human promyelocytic leukemia HL-60 cells. In this study, the in vivo effects of AC on leukemia WEHI-3 cells and immune responses such as phagocytosis and natural killer (NK) cell activity were investigated. The weights of the livers and spleens were decreased in the AC-treated groups compared to the control groups. The AC treatment increased the percentage of CD3 and CD19 marker cells in WEHI-3-injected mice, indicating that the precursors of T and B cells were inhibited. The AC treatment promoted the activity of macrophage phagocytosis in the peripheral blood mononuclear cells (PBMC) and peritoneal cells. It was found that the NK cells front mice after treatment with AC can kill the YAC-1 target cells. Therefore, the AC treatment increased NK cell activity. In conclusion, AC can affect WEHI-3 cells in vivo and promote macrophage and NK cell activities.

• 出版日期2009-8
• 单位中国医科大学