Activation of TRAIL-DR5 pathway promotes sensorineural degeneration in the inner ear

作者：Kao Shyan Yuan; Soares Vitor Y R; Kristiansen Arthur G; Stankovic Konstantina M^*

来源：AGING CELL, 2016, 15(2): 301-308.

DOI：10.1111/acel.12437

• TRAIL
• DR5
• OPG
• cochlea
• hair cells
• spiral ganglion neuron

Tumor necrosis factor (TNF) family cytokines are important mediators of inflammation. Elevated levels of serum TNF- are associated with human sensorineural hearing loss via poorly understood mechanisms. We demonstrate, for the first time, expression of TNF-related apoptosis-inducing ligand (TRAIL) and its signaling death receptor 5 (DR5) in the murine inner ear and show that exogenous TRAIL can trigger hair cell and neuronal degeneration, which can be partly prevented with DR5-blocking antibodies.

• 出版日期2016-4