Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia

作者：Ottone T; Cicconi L; Hasan S K; Lavorgna S; Divona M; Voso M T; Montefusco E; Melillo L; Barragan E; Platzbecker U; Gianni L; Hubmann M; Pagoni M; Amadori S; Lo Coco F^*

来源：Leukemia Research, 2012, 36(4): 474-478.

DOI：10.1016/j.leukres.2011.10.015

• Therapy-related leukemia
• Acute Promyelocytic Leukemia
• IDHs mutation
• DNMT3A mutation
• TET2 mutation

Therapy-related acute promyelocytic leukemia (t-APL) has been reported as a late complication of exposure to radiotherapy and/or chemotherapeutic agents targeting DNA topoisomerase II. We have analyzed in t-APL novel gene mutations recently associated with myeloid disorders. Unlike previous reports in acute myeloid leukemia (AML), our results showed neither IDHs nor TET2 mutations in t-APL. However we found an R882H mutation in the DNMT3A gene in a patient with t-APL suggesting a possible role of this alteration in the pathogenesis of t-APL.

• 出版日期2012-4