Anti-lung cancer effects of novel ginsenoside 25-OCH(3)-PPD

作者：Wang Wei; Rayburn Elizabeth R; Hang Jie; Zhao Yuqing; Wang Hui; Zhang Ruiwen^*

来源：Lung Cancer, 2009, 65(3): 306-311.

DOI：10.1016/j.lungcan.2008.11.016

• Panax notoginseng
• 25-OCH(3)-PPD
• Ginsenoside
• Natural products
• Lung cancer
• Apoptosis
• Cell cycle arrest

20(S)-25-methoxyl-dammarane-3 beta, 12 beta, 20-triol (25-OCH(3)-PPD), a newly identified natural product from Panax notoginseng, exhibits activity against a variety of cancer cells. Herein, we report the effects of this compound on human A549, H358, and H838 lung cancer cells, and compare these effects with a control lung epithelial cell line, BEAS-2B. 25-OCH(3)-PPD decreased survival, inhibited proliferation, and induced apoptosis and G1 cell cycle arrest in the lung cancer cell lines. The P. notoginseng compound also decreased the levels of proteins associated with cell proliferation and cell survival. Moreover, 25-OCH(3)-PPD inhibited the growth ofA549 lung cancer xenograft tumors. 25-OCH(3)-PPD demonstrated low toxicity to non-cancer cells, and no observable toxicity was seen when the compound was administered to animals. In conclusion, our preclinical data indicate that 25-OCH(3)-PPD is a potential therapeutic agent in vitro and in vivo, and further preclinical and clinical development of this agent for lung cancer is warranted.

• 出版日期2009-9
• 单位中国科学院; 中国科学院上海生命科学研究院; 沈阳药科大学