Accuracy and efficacy of intrathecal administration of morphine sulfate for treatment of intractable pain using the Prometra (R) Programmable Pump

作者：Rauck Richard^*; Deer Timothy; Rosen Steve; Padda Gurpreet; Barsa John; Dunbar Elmer; Dwarakanath Gopala

来源：Neuromodulation, 2010, 13(2): 102-107.

DOI：10.1111/j.1525-1403.2009.00257.x

• Back pain
• chronic pain
• implantable infusion pump
• intractable pain
• morphine

Objectives:
Intrathecal infusion pumps are increasingly used to deliver analgesics for chronic intractable pain. This trial evaluated the accuracy and efficacy of the new Prometra (R) Programmable Pump System for intrathecal administration of morphine sulfate to treat chronic intractable pain.
Methods:
One hundred and ten patients were given continuous intrathecal morphine sulfate and assessed monthly for up to six months. Accuracy was determined as the ratio of delivered to programmed drug volume (DP ratio). Efficacy was assessed using the visual analog and numeric rating scales and the Oswestry Disability Index.
Results:
The mean accuracy of the Prometra pump was 97.1%, with a 90% confidence interval of 96.2-98.0%. Decreases in pain and disability were reported at 68.4% of patient visits. No unanticipated adverse events or device complications were reported.
Conclusions:
The Prometra pump provides an accurate, effective, and safe system for intrathecal administration of morphine sulfate for treatment of chronic intractable pain.

• 出版日期2010-4