Ammonium Chloride-Catalyzed Three-Component Reaction for the Synthesis of Fused 4H-Chromene Derivatives in Aqueous Medium

作者：Bhattacharjee Suchandra^*; Das Deb K; Khan Abu T

来源：Synthesis, 2014, 46(1): 73-80.

DOI：10.1055/s-0033-1340082

• 4H-chromenes
• salicylaldehydes
• cyclic 1
• 3-diketones
• thiols
• ammonium chloride
• aqueous medium
• multicomponent reactions (MCRs)

An efficient one-pot process was developed to synthesize 4H-chromene derivatives using a three-component reaction involving salicylaldehydes, cyclic 1,3-diketones, and thiols in an aqueous medium at room temperature. This protocol was accomplished using the inexpensive and readily available catalyst NH4Cl. The attractive features of this protocol are: use of inexpensive catalyst NH4Cl, good yields, and mild and environmentally benign reaction conditions.

• 出版日期2014-1