Applanation optical coherence elastography: noncontact measurement of intraocular pressure, corneal biomechanical properties, and corneal geometry with a single instrument

作者：Singh Manmohan; Han Zhaolong; Nair Achuth; Schill Alexander; Twa Michael D; Larin Kirill V

来源：Journal of Biomedical Optics, 2017, 22(2): 020502.

DOI：10.1117/1.JBO.22.2.020502

• optical coherence tomography
• optical coherence elastography
• cornea
• intraocular pressure
• applanation tonometry
• biomechanical properties
• keratoconus
• corneal collagen crosslinking

Current clinical tools provide critical information about ocular health such as intraocular pressure (IOP). However, they lack the ability to quantify tissue material properties, which are potent markers for ocular tissue health and integrity. We describe a single instrument to measure the eye-globe IOP, quantify corneal biomechanical properties, and measure corneal geometry with a technique termed applanation optical coherence elastography (Appl-OCE). An ultrafast OCT system enabled visualization of corneal dynamics during noncontact applanation tonometry and direct measurement of micro air-pulse induced elastic wave propagation. Our preliminary results show that the proposed Appl-OCE system can be used to quantify IOP, corneal biomechanical properties, and corneal geometry, which builds a solid foundation for a unique device that can provide a more complete picture of ocular health.

• 出版日期2017-2