MUC1 and HER2 might be Associated with Invasive Phenotype of Intraductal Papillary Mucinous Neoplasm

作者：Ohira Go; Kimura Kenjiro^*; Yamada Nobuya; Amano Ryosuke; Nakata Bunzo; Doi Yosuke; Murata Akihiro; Yashiro Masakazu; Tanaka Sayaka; Ohsawa Masahiko; Wakasa Kenichi; Hirakawa Kosei

来源：Hepato-Gastroenterology, 2013, 60(125): 1067-1072.

DOI：10.5754/hge121268

• Intraductal papillary mucinous neoplasm
• MUC1
• HER2

Background/Aims: The purpose of this study was to clarify the biomarkers which distinguish invasive intraductal papillary mucinous neoplasms (IPMNs) from non-invasive IPMNs. Methodology: In-tumor specimens from sixty patients with IPMNs (42 non-invasive IPMNs and 18 invasive IPMNs) who underwent surgical resection at our institute, were analyzed for correlation between the immunohistochemical expression levels of MUC1, MUC2, MUC4, MUC5AC, p53, VEGFR2, HER2, and HER3. Results: The 5-year survival rate was 100% in non-invasive IPMNs, while that of invasive IPMNs was only 36.5%. MUC1, MUC4, HER2 and HER3 were significantly associated with invasive IPMNs in univariate analysis. Multivariate analysis revealed that MUC1 and HER2 were significantly associated with invasive IPMNs. The 5-year survival of IPMN patients with either MUC1-positive and/or HER2positive (54.5%) is significantly poorer than that of IPMN patients with MUC1 negative and HER2 negative (100%). Conclusions: MUC1 and HER2 might be closely associated with invasive phenotype of IPMNs.

• 出版日期2013-8