Antibacterial anthraquinone derivatives isolated from a mangrove-derived endophytic fungus Aspergillus nidulans by ethanol stress strategy

作者：Yang, Sui-Qun; Li, Xiao-Ming; Xu, Gang-Ming; Li, Xin; An, Chun-Yan; Wang, Bin-Gui^*

来源：Journal of Antibiotics, 2018, 71(9): 778-784.

DOI：10.1038/s41429-018-0063-x

• POLYKETIDES
• METABOLITES

Three new natural products, including a new anthraquinone derivative isoversicolorin C (1), a new xanthone analog isosecosterigmatocystin (2), and a new amino acid derivative, glulisine A (3), along with six related metabolites (4-9) were isolated from the culture broth and mycelia extracts of the mangrove-derived endophytic fungus Aspergillus nidulans MA-143 under 0.1% ethanol stress. Their structures were elucidated by detailed analysis of their NMR spectra, ECD spectrum, and X-ray crystallographic experiments. Compounds 1 and 4 showed potent antibacterial activity against some of the tested microbes.

• 出版日期2018-9
• 单位中国科学院大学; 中国科学院海洋研究所