Genetic and biological characterization of avian influenza H5N1 viruses isolated from wild birds and poultry in Western Siberia

作者：Sharshov Kirill^*; Romanovskaya Alesia; Uzhachenko Roman; Durymanov Alexander; Zaykovskaya Anna; Kurskaya Olga; Ilinykh Philipp; Silko Nikita; Kulak Mikhail; Alekseev Alexander; Zolotykh Sergei; Shestopalov Alexander; Drozdov Iliya

来源：Archives of Virology, 2010, 155(7): 1145-1150.

DOI：10.1007/s00705-010-0676-2

Three viruses included in the study were isolated from dead birds (A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, and A/duck/Tuva/01/2006), whereas the virus A/common gull/Chany/P/2006 was isolated from an apparently healthy gull during outbreaks of highly pathogenic avian influenza in Russia in 2006. The intravenous pathogenicity index (IVPI) of viruses A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, and A/duck/Tuva/01/2006 ranged from 2.7 to 3.0, while the virus A/common gull/Chany/P/2006 had a markedly lower IVPI of 1.7. The virus A/common gull/Chany/P/2006 had a unique pattern of six amino acid substitutions in the regions of viral proteins crucial for virulence of H5N1 viruses. We hypothesize that these substitutions may affect the pathogenicity of A/common gull/Chany/P/2006.

• 出版日期2010-7