New Metabolites from the Marine-derived Fungus Aspergillus fumigatus

作者：Afiyatullov Shamil Sh^*; Zhuravleva Olesya I; Antonov Alexandr S; Kalinovsky Anatoly I; Pivkin Michail V; Menchinskaya Ekaterina S; Aminin Dmitry L

来源：Natural Product Communications, 2012, 7(4): 497-500.

DOI：10.1177/1934578x1200700421

• Aspergillus fumigatus
• Marine-derived fungus
• Spiro-indole diketopiperazines
• Fumiquinazolines
• Nordammarane
• Triterpenoid

A new alkaloid, fumiquinazoline K (1), and a new nordammarane triterpenoid (2), together with three known diketopiperazines (3-5) and tryptoquivaline F (6) have been isolated from a marine strain of Aspergillus fumigatus KMM 4631 associated with the soft coral Sinularia sp. Their structures were determined by FIR-MS and ID and 2D NMR. Compounds 3-5 exhibit weak cytotoxicity against cytoplasm non-specific esterase in Ehrlich carcinoma cells. Compound 3 also induces early apoptosis of the same cells in a non-toxic range of concentrations.

• 出版日期2012-4