Mannich products of kojic acid and N-heterocycles and their Ru(II)-arene complexes: Synthesis, characterization and stability

作者：Kasser Johanna H; Kandioller Wolfgang; Hartinger Christian G^*; Nazarov Alexey A; Arion Vladimir B; Dyson Paul J; Keppler Bernhard K

来源：Journal of Organometallic Chemistry, 2010, 695(6): 875-881.

DOI：10.1016/j.jorganchem.2010.01.007

• Kojic acid
• Mannich reaction
• Ruthenium(II)-arene complexes
• Stability studies
• Synthesis

Ru(II)-eta(6)-p-cymene compounds bearing pyrone-derived ligands, which were obtained by Mannich reaction with piperidine and related analogues, have been synthesized. The compounds were characterized by NMR spectroscopy, mass spectrometry, thermogravimetric analysis and in the case of 2-(2,6-dimethyl-morpholin-4-ylmethyl)-3-hydroxy-6-hydroxymethyl-pyran-4-one by X-ray diffraction analysis. The chlorido complexes are prone to aquation in aqueous solution which results in the formation of dimers. Dimer formation can be inhibited by in situ replacement of the chlorido ligand by imidazole yielding compounds which are significantly more stable in water, as demonstrated by (1)H NMR spectroscopy.

• 出版日期2010-3-15