Molecular modeling of 8-methoxy quinolone analogues by using quantitative structure activity relationship

作者：Srivastava A K; Pathak Vinay Kumar; Srivastava Akanchha; Pandey Avni

来源：Journal of Saudi Chemical Society, 2010, 14(2): 217-222.

DOI：10.1016/j.jscs.2010.02.006

• QSAR
• Steric parameters
• Electronic parameter
• Cytotoxicity

Quantitative structure activity relationship (QSAR) studies on a series of 8-methoxy quinolone are found to correlate well with steric parameters and electronic parameter. The results are critically discussed on the basis of regression data, Pogliani factor Q and cross validation technique. The results are found to be useful in discussing the mechanism of drug - receptor interaction. Steric parameter 'Mr' and electronic parameter 'Pz' gives the best model.

• 出版日期2010-4