NAIP inflammasomes give the NOD to bacterial ligands

作者：Maltez Vivien I; Miao Edward A^*

来源：Trends in Immunology, 2014, 35(11): 503-504.

DOI：10.1016/j.it.2014.10.002

NLRs are innate immune sensors that monitor the sanctity of the cytosolic compartment. In a recent paper in Molecular Cell, Tenthorey et al. reveal a novel ligand-sensing interface within regions of the oligomerization domain of the NAIPs, rather than within the leucine-rich repeats, as was anticipated.

• 出版日期2014-11