Antibiotic resistance mechanisms of Vibrio cholerae

作者：Kitaoka Maya; Miyata Sarah T; Unterweger Daniel; Pukatzki Stefan^*

来源：Journal of Medical Microbiology, 2011, 60(4): 397-407.

DOI：10.1099/jmm.0.023051-0

As the causative agent of cholera, the bacterium Vibdo cholerae represents an enormous public health burden, especially in developing countries around the world. Cholera is a self-limiting illness; however, antibiotics are commonly administered as part of the treatment regimen. Here we review the initial identification and subsequent evolution of antibiotic-resistant strains of V cholerae. Antibiotic resistance mechanisms, including efflux pumps, spontaneous chromosomal mutation, conjugative plasmids, SXT elements and integrons, are also discussed. Numerous multidrug-resistant strains of V cholerae have been isolated from both clinical and environmental settings, indicating that antibiotic use has to be restricted and alternative methods for treating cholera have to be implemented.

• 出版日期2011-4