Allergic bronchopulmonary aspergillosis in cystic fibrosis

作者：Steiss J O^*; Lindemann H

来源：Allergologie, 2013, 36(6): 275-281.

DOI：10.5414/ALX01594

• allergic bronchopulmonary aspergillosis
• cystic fibrosis
• pathophysiology
• diagnosis
• therapy

Allergic bronchopulmonary aspergillosis (ABPA) is the most common type of allergic bronchopulmonary mycosis. It is caused by an immunological reaction to the ubiquitary mould fungus Aspergillus fumigatus. This is a combination of a type-I and type-III reaction as described by Coombs and Gell, constituting a serious and, with advancing age, common complication in patients with cystic fibrosis. The disease is frequently identified and treated late. The diagnosis of ABPA in an early stage at a time when no persistent changes have occurred in the bronchial wall and the lung parenchyma is not destroyed is of crucial importance with regard to the prognosis of the disease. ABPA is a complex disease with specific clinical symptoms, radiological features, and serological markers. Current aspects of diagnosis and therapy are addressed in this report.

• 出版日期2013-6