Aqueous chlorination of diclofenac: Kinetic study and transformation products identification

作者：Soufan M; Deborde M^*; Legube B

来源：Water Research, 2012, 46(10): 3377-3386.

DOI：10.1016/j.watres.2012.03.056

• Pharmaceuticals
• Diclofenac
• Chlorination
• Kinetic
• By-products
• Mechanism

Diclofenac reactivity and fate during water chlorination was investigated in this work. In the first step, chlorination kinetic of diclofenac (DCF) was studied in the pH range of 4-10 at 20 +/- 2 degrees C and in the presence of an excess of total chlorine. A second-order reaction (first-order relative to DCF concentration and first-order relative to free chlorine concentration) was shown with rate constant about 3.89 +/- 1.17 M-1 s(-1) at pH 7. The elementary reactions (i.e. reactions of hypochlorous acid (HOCl) with neutral and ionized forms of DCF, and acid-catalysed reaction of HOCl with neutral and ionized forms of DCF) were proposed to explain the pH-dependence of the rate constants and intrinsic constant of each of them were calculated. In the second step, several degradation products formed during chlorination of DCF were identified. These compounds could come from an initial chlorine electrophilic attack on aromatic ring or amine function of DCF. Some of these chlorinated derivatives seem to accumulate in solution in the presence of an excess of chlorine.

• 出版日期2012-6-15