Differential expression of interferon-gamma, IL-4 and IL-10 in peripheral blood mononuclear cells during early pregnancy of the bovine

作者：Yang, Ling^*; Wang, Yongxiang; Li, Shujing; Zhu, Meixia; He, Kaili; Yao, Xiaolei; Zhang, Leying

来源：Reproductive Biology, 2018, 18(3): 312-315.

DOI：10.1016/j.repbio.2018.06.005

• Cattle
• Peripheral blood mononuclear cells
• Pregnancy
• T helper cytokine

Maternal systemic immune response is regulated by conceptus-derived signals through peripheral blood mononuclear cells (PBMCs) via blood circulation during early pregnancy in cattle. In this study, the PBMCs from day 18 in non-pregnant cows and days 14, 18 and 30 in pregnant cows were used to explore the expression of interferon-gamma (IFN-gamma), interleukin 4 (IL-4) and IL-10, and the plasma progesterone (P4) concentration was also determined. The results showed that the expression levels of mRNA and the protein of IFN-gamma were lower and that IL-4 and IL-10 were higher in the PBMCs from the pregnant cows than in those of non-pregnant cows. From this study, early pregnancy induced a lower Th1 immunity (IFN-gamma) and a higher Th2 immunity (IL-4 and IL-10) in the PBMCs, which may be related to interferon-tau and P4, thereby contributing to successful pregnancy in cattle.

• 出版日期2018-9
• 单位河北工程大学