Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG

作者:Szekely Gyoergy; Schaepertoens Marc; Gaffney Piers R J*; Livingston Andrew G
来源:Polymer Chemistry, 2014, 5(3): 694-697.
DOI:10.1039/c3py01367g

摘要

Highly monodisperse, heterobifunctional poly(ethylene glycol) (PEG) was prepared by iterative chain extension of a PEGylated homostar using an octagol (EG(8)) building block to give MeO-EG(24)-OH in high purity. The branched structure facilitated purification of intermediates by chromatography, and mono-functionalization of the chain termini. This approach should be extendable to other classes of oligomers.

  • 出版日期2014-2-7