Mitochondria-Targeted Antioxidant Mitoquinone Reduces Cisplatin-Induced Ototoxicity in Guinea Pigs

作者：Tate Alan D; Antonelli Patrick J; Hannabass Kyle R; Dirain Carolyn O

来源：Otolaryngology - Head and Neck Surgery, 2017, 156(3): 543-548.

DOI：10.1177/0194599816678381

• hearing loss
• mitoquinone
• cisplatin
• ototoxicity
• guinea pigs

Objective. To determine if mitoquinone (MitoQ) attenuates cisplatin-induced hearing loss in guinea pigs.
Study Design. Prospective and controlled animal study.
Setting. Academic, tertiary medical center.
Subjects and Methods. Guinea pigs were injected subcutaneously with either 5 mg/kg MitoQ (n = 9) or normal saline (control, n = 9) for 7 days and 1 hour before receiving a single dose of 10 mg/kg cisplatin. Auditory brainstem response thresholds were measured before MitoQ or saline administration and 3 to 4 days after cisplatin administration.
Results. Auditory brainstem response threshold shifts after cisplatin treatment were smaller by 28 to 47 dB in guinea pigs injected with MitoQ compared with those in the control group at all tested frequencies (4, 8, 16, and 24 kHz, P=.0002 to .04). Scanning electron microscopy of cochlear hair cells showed less outer hair cell loss and damage in the MitoQ group.
Conclusion. MitoQ reduced cisplatin-induced hearing loss in guinea pigs. MitoQ appears worthy of further investigation as a means of preventing cisplatin ototoxicity in humans.

• 出版日期2017-3