Novel metabolically stable and functionally active mimetic of spermidine

作者：Khomutov M A^*; Hyvonen M T; Simonian A R; Vepsalainen J; Alhonen L; Kochetkov S N; Keinanen T A

来源：Russian Journal of Bioorganic Chemistry, 2011, 37(2): 225-230.

DOI：10.1134/S1068162011020075

• polyamines
• spermidine analogues
• gamma-MeSpd
• spermine synthase
• spermine/spermidine N(1)-acetyltransferase
• DU145 cells

Earlier unknown 1,8-diamino-3-methyl-4-azanonane (gamma-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N (1)-acetyltransferase nor spermine synthase, but was capable to support the growth of DU145 cells having depleted polyamine pools. Such a combination of gamma-MeSpd properties discloses novel opportunities to study cellular functions of catabolically unstable and easily interconvertible spermine and spermidine.

• 出版日期2011-3