An expeditious synthesis of benzimidazole derivatives catalyzed by Lewis acids

作者：Zhang, Zhan-Hui; Yin, Liang; Wang, Yong-Mei^*

来源：Catalysis Communications, 2007, 8(7): 1126-1131.

DOI：10.1016/j.catcom.2006.10.022

• benzimidazole
• o-phenylenediamines
• orthoesters
• Lewis acids
• zirconium tetrachloride

An expeditious and efficient route for the synthesis of benzimidazole derivatives by the reaction of o-phenylenediamines with ortho-esters in the presence of Lewis acids was described. ZrCl4, SnCl4 center dot 5H(2)O, TiCl4, BF3 center dot Et2O, ZrOCl2 center dot 8H(2)O and HfCl4 exhibited high catalytic activity for this transformation.

• 出版日期2007-7
• 单位元素有机化学国家重点实验室; 南开大学