Association of Thyroid Autoantibodies and Thyroid Function with Moyamoya Disease: a prospective study in Western China

作者：Chen, Jian-bin; Lei, Ding; He, Min; Sun, Hong; You, Chao; Zhou, Liang-xue^*

来源：Journal of Neurological Sciences-Turkish, 2014, 31(4): 709-717.

• Thyroid autoantibodies
• Thyroid function
• Moyamoya disease
• Disease progression

Objective: The aim of this study was to further investigate whether elevated thyroid autoantibodies and increased thyroid function associated with moyamoya disease (MMD). @@@ Methods: We prospectively studied angiographically identified patients with idiopathic MMD and compared clinical characteristics, serum thyroid autoantibodies and thyroid hormones levels, T cell subsets between MMD patients and healthy controls by employing a 1: 1 case-control study design. We assessed the disease progressions of MMD patients associated with thyroid autoimmune disease. @@@ Results: A total of 52 patients with MMD and 52 healthy controls were included. The prevalence of elevated thyroid autoantibodies (p < 0.001) and increased thyroid p < 0.001) were significantly higher in patients with MMD than in healthy controls. After adjustment for the covariates, both elevated thyroid autoantibodies (OR, 6.41; 95% CI, 1.24-33.24; p =0.027) and increased thyroid OR, 12.11; 95% CI, 1.39-105.74; p =0.024) were significantly associated with contributions to MMD development. Patients of MMD after antithyroid therapy experienced significantly fewer progressions of Suzuki stages (p =0.011 for both). @@@ Conclusions: The findings confirmed that underlying thyroid autoimmune abnormalities associate with MMD. Antithyroid therapy would be beneficial to the conditions of MMD patients with thyroid disease.

• 出版日期2014
• 单位四川大学