Nanostructural materials increase mineralization in bone cells and affect gene expression through miRNA regulation

作者：Mahmood Meena; Li Zhiguang; Casciano Daniel; Khodakovskaya Mariya V; Chen Tao; Karmakar Alokita; Dervishi Enkeleda; Xu Yang; Mustafa Thikra; Watanabe Fumiya; Fejleh Ashley; Whitlow Morgan; Al Adami Mustafa; Ghosh Anindya; Biris Alexandru S^*

来源：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2011, 15(11): 2297-2306.

DOI：10.1111/j.1582-4934.2010.01234.x

• nanomaterials
• bone cells
• mineralization
• miRNA regulation

We report that several nanomaterials induced enhanced mineralization (increased numbers and larger areas of mineral nests) in MC3T3-E1 bone cells, with the highest response being induced by silver nanoparticles (AgNPs). We demonstrate that AgNPs altered microRNA expression resulting in specific gene expression associated with bone formation. We suggest that the identified essential transcriptional factors and bone morphogenetic proteins play an important role in activation of the process of mineralization in bone cells exposed to AgNPs.

• 出版日期2011-11