Neuropsychiatric Lupus in clinical practice

作者：Alessi Helena; Dutra Livia Almeida^*; Braga Neto Pedro; Pedroso Jose Luiz; Toso Fabio F; Kayser Cristiane; Barsottini Orlando G P

来源：Arquivos de Neuro-Psiquiatria, 2016, 74(12): 1021-1030.

DOI：10.1590/0004-282X20160150

• systemic lupus erythematosus
• lupus vasculitis
• central nervous system
• seizures
• myelitis
• autoimmune diseases

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving multiple organs, characterized by the production of autoantibodies and the development of tissue injury. The etiology of SLE is partially known, involving multiple genetic and environmental factors. As many as 50% of patients with SLE have neurological involvement during the course of their disease. Neurological manifestations are associated with impaired quality of life, and high morbidity and mortality rates. Nineteen neuropsychiatric syndromes have been identified associated with SLE, and can be divided into central and peripheral manifestations. This article reviews major neuropsychiatric manifestations in patients with SLE and discusses their clinical features, radiological findings and treatment options.

• 出版日期2016-12