Acid-Labile Cys-Protecting Groups for the Fmoc/tBu Strategy: Filling the Gap

作者：Gongora Benitez Miriam; Mendive Tapia Lorena; Ramos Tomillero Ivan; Breman Arjen C; Tulla Puche Judit^*; Albericio Fernando

来源：Organic Letters, 2012, 14(21): 5472-5475.

DOI：10.1021/ol302550p

To address the existing gap in the current set of acid-labile Cys-protecting groups for the Fmoc/fBu strategy, diverse Fmoc-Cys(PG)-OH derivatives were prepared and incorporated into a model tripeptide to study their stability against TFA. S-Dpm proved to be compatible with the commonly used S-Trt group and was applied for the regioselecive construction of disulfide bonds.

• 出版日期2012-11-2