A Convenient and Efficient Method for the Synthesis of a Novel Series of N-Butyl-1,4-oxazino[2 ',3 ':4,5]pyrano[3,2-c] quinolinones

Hassanin Hany M.; Hassan Mohamed M.<sup>*</sup>

doi:10.21577/0103-5053.20170202

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A Convenient and Efficient Method for the Synthesis of a Novel Series of N-Butyl-1,4-oxazino[2 ',3 ':4,5]pyrano[3,2-c] quinolinones

作者：Hassanin Hany M.; Hassan Mohamed M.^*

来源：Journal of the Brazilian Chemical Society, 2018, 29(4): 792-800.

DOI：10.21577/0103-5053.20170202

摘要

We design and describe here a simple route for the synthesis of a new multi heterocycle fused 1,4-oxazinopyranoquinolinones compatible with many functional groups. This method proceeds through various cyclic condensation reactions of (3-amino or 3-nitropyrano)[3,2-c] quinoline-2,5(6H)-dione precursors with different 1,2-bifunctional electrophiles. The synthesized compounds are confirmed by infrared (IR), proton (H-1) and carbon-13 (C-13) nuclear magnetic resonance (NMR) spectroscopy and electrospray ionization mass spectrometry (ESI-MS).