Development of pharmaceutical clear gel based on Peceol (R), lecithin, ethanol and water: Physicochemical characterization and stability study

作者：Mouri Abdelkader; Diat Olivier; El Ghzaoui Abdeslam; Ly Isabelle; Dorandeu Christophe; Maurel Jean Claude; Devoisselle Jean Marie; Legrand Philippe^*

来源：Journal of Colloid and Interface Science, 2015, 457: 152-161.

DOI：10.1016/j.jcis.2015.06.010

• Phase diagram
• Mono- di- tri-glycerides
• Lecithin
• Gel
• Polar lipids
• W/O microemulsion
• Inverted hexagonal phase

The phase behavior of the four-components Peceol (R)/lecithin/ethanol/water system has been studied in a part of the phase diagram poor in water and varying the lecithin/Peceol (R) ratio. Using several complementary techniques such as Karl Fischer titration, rheology, polarized microscopy and SAXS measurements several nanostructures of the complex systems were identified. W/O microemulsion (L-2) as well as an inverted hexagonal (H-2) liquid-crystal phase were studied. The analysis of the different phase transitions allows us to understand the effect of lecithin on the water solubilization efficiency of this clear gel and to show its pharmaceutical interest among lecithin organogels.

• 出版日期2015-11-1
• 单位中国地震局