In Vitro Analyses of Ethanol Activity against Candida albicans Biofilms

作者：Rane Hallie S; Bernardo Stella M; Walraven Carla J; Lee Samuel A^*

来源：Antimicrobial Agents and Chemotherapy, 2012, 56(8): 4487-4489.

DOI：10.1128/AAC.00263-12

Candida albicans is a common cause of catheter-related bloodstream infections (CR-BSI). Ethanol (EtOH) lock therapy has been attempted despite limited data on optimal dose and duration. Concentrations of 35% EtOH or higher for a minimum of 4 h demonstrated a %26gt;99% reduction in mature C. albicans biofilm metabolic activity and prevented regrowth. Concentrations of 10% EtOH or higher reduced C. albicans biofilm formation by %26gt;99%. Further investigation of EtOH lock therapy for treatment and prevention of C. albicans CR-BSI is warranted.

• 出版日期2012-8