Acetylation-dependent regulation of mitochondrial ALDH2 activation by SIRT3 mediates acute ethanol-induced eNOS activation

作者：Xue, Li; Xu, Feng; Meng, Lujing; Wei, Shujian; Wang, Jiali; Hao, Panpan; Bian, Yuan; Zhang, Yun; Chen, Yuguo^*

来源：FEBS LETTERS, 2012, 586(2): 137-142.

DOI：10.1016/j.febslet.2011.11.031

• Aldehyde dehydrogenase 2
• Acetylation
• Endothelial nitric-oxide synthase
• Ethanol
• Reactive oxygen species
• SIRT3

Moderate alcohol consumption has beneficial effects on endothelial nitric-oxide synthase (eNOS) activation, which can engender an array of anti-atherogenic actions. Here we show that in human aortic endothelial cells (HAECs), rapid activation of mitochondrial aldehyde dehydrogenase 2 (ALDH2) mediates ethanol-induced eNOS activation by preventing reactive oxygen species (ROS) accumulation. Furthermore, activation of ALDH2 by ethanol is due to its hyperacetylation by SIRT3 inactivation. These data suggest that ethanol-induced eNOS activation in HAECs may be dependent on ALDH2 hyperacetylation by SIRT3 inactivation.

• 出版日期2012-1-20
• 单位山东大学