Activated IL-22 pathway occurs in the muscle tissues of patients with polymyositis or dermatomyositis and is correlated with disease activity

作者：Ciccia Francesco; Rizzo Aroldo; Alessandro Riccardo; Guggino Giuliana; Maugeri Rosario; Saieva Laura; Cannizzaro Alessandra; Giardina AnnaRita; De Leo Giacomo; Iacopino Domenico Gerardo; Triolo Giovanni^*

来源：Rheumatology, 2014, 53(7): 1307-1312.

DOI：10.1093/rheumatology/keu005

• IL-22
• IL-22R1
• IL-17
• p-STAT3
• polymyositis
• dermatomyositis

Methods. Levels of IL-22, IL-22R1, IL-22BP and STAT3 mRNA were quantified by RT-PCR. The expression of IL-22, IL-22R1, IL-22BP and p-STAT3 was also analysed using immunohistochemistry. %26lt;br%26gt;Results. Significant modulation of the IL-22 pathway was observed in inflammatory myopathic tissues. In particular, a significant overexpression of IL-22 at the protein but not the mRNA level was observed in PM/DM tissues and was correlated with myositis activity. IL-22R1 aberrant expression was also observed among infiltrating mononuclear cells and necrotic muscle cells. IL-22BP, which inhibits IL-22 signalling, was expressed only in some muscle fibres in PM/DM patients. %26lt;br%26gt;Conclusion. Our findings indicate that the IL-22 pathway is activated in inflammatory myopathic tissues and may be involved in the induction of muscle inflammatory processes and muscle necrosis.

• 出版日期2014-7