A Phosphine-Free Approach to Primary Amides by Palladium-Catalyzed Aminocarbonylation of Aryl and Heteroaryl Iodides Using Methoxylamine Hydrochloride as an Ammonia Equivalent

作者：Gadge Sandip T; Bhanage Bhalchandra M^*

来源：Synlett, 2014, 25(1): 85-88.

DOI：10.1055/s-0033-1340162

• amides
• carbonylation
• palladium
• catalysis
• phosphine-free
• cross-coupling

The palladium-catalyzed synthesis of primary amides by aminocarbonylation of aryl and heteroaryl iodides under phosphine-free conditions is reported for the first time. Methoxylamine hydrochloride, acting as an ammonia equivalent, undergoes sequential carbonylation and demethoxylation under mild reaction conditions. The procedure does not require a phosphine ligand and takes place in short reaction times at low temperatures to provide the products in excellent yields.

• 出版日期2014-1-2