Novel catalase loaded nanocores for the treatment of inflammatory bowel diseases

作者：Parihar Arun K S; Srivastava Shikha; Patel Satish; Singh Manju R; Singh Deependra

来源：Artificial Cells, Nanomedicine and Biotechnology, 2017, 45(5): 981-989.

DOI：10.1080/21691401.2016.1198363

• Antioxidant enzymes
• catalase
• hydroxyapatite
• IBD
• nanoceramic core

Inflammatory bowel disease (IBD) is an inflammatory disorder of the digestive tract reported to be primarily caused by oxidative stress. In this study, alginate encapsulated nanoceramic carriers were designed to deliver acid labile antioxidant enzyme catalase orally. Complete system was characterized for size, loading efficiency, in vitro antioxidant assay and in vitro release. The prepared nanoceramic system was found to be spherical with diameter of 925 +/- 6.81 nm. The in vitro release data followed the Higuchi model in acidic buffer whereas in alkaline pH sustained and almost first order release of enzyme was observed up to 6 h.

• 出版日期2017